![]() ![]() Our data showed that BSYZ increased aspartate and betaine levels, while decreasing choline levels. ![]() Finally, pharmacological validation was conducted to explore the effects of BSYZ on D-gal-induced oxidative stress, neuroinflammation, and neuronal apoptosis. Then based on the comparison of differential metabolites implied that BSYZ ameliorated mitochondrial dysfunction through choline metabolic pathway in D-gal-treated rats. Secondly, the potential metabolic mechanism of BSYZ was explored by 1H-NMR metabolomics analysis. This study is the first to investigate the effect of BSYZ on D-gal-induced learning memory in rats. The previous study demonstrated that Bushen-Yizhi formula (BSYZ), a traditional Chinese medicine formula, is effective in reducing neurodegeneration. Age-related decline in mitochondrial function and oxidative stress is strongly associated with neurodegeneration. As a major risk factor for neurodegenerative diseases, aging has become a heavy health care burden worldwide.
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